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By M. Maurer

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Thus the addition of quinidine sulphate increases the bioavailability of dextromethorphan hydrobromide (Olney & Rosen, 2010). AVP-923 was tested in two phase III trials in ALS patients with pseudobulbar affect (PBA), which is characterized by emotional dysregulation, such as uncontrollable outbursts of laughing or crying that are inappropriate to the emotions being experienced (Garnock-Jones, 2011; Olney & Rosen, 2010). , 2004). , 1990). 10 Brain-derived neurotrophic factor (BDNF) The neuroprotective growth factor BDNF has been evaluated in a phase I/II clinical trial which reported a trend for prolonged survival after subcutaneous infusion (The BDNF Study Group & Bradley, 1995), a result which could not be reproduced in the subsequent phase III clinical trial (The BDNF Study Group (Phase III), 1999).

151-157. , Fornai, F. & Siciliano, G. (2011). Strategies for clinical approach to neurodegeneration in amyotrophic lateral sclerosis. Arch Ital Biol, Vol. 149, No. 1, pp. 151-167. , Rube, D. & et al. (1986). A double-blind, placebo-controlled trial of TRH in amyotrophic lateral sclerosis. Neurology, Vol. 36, No. 2, pp. 141-145. K. D. (2010). Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials. Am J Hosp Palliat Care, Vol. 27, No. 5, pp.

1993). Anti-glutamate therapy in amyotrophic lateral sclerosis: a trial using lamotrigine. Can J Neurol Sci, Vol. 20, No. 4, pp. 297-301. A. (2007). A. J. ), pp. , Amsterdam. K. R. (1980). Phthalazinol, thrombocytopenia, and amyotrophic lateral sclerosis. Arch Neurol, Vol. 37, No. 5, pp. 320. M. H. (1993). Amyotrophic lateral sclerosis presenting with psychosis. Psychosomatics, Vol. 34, No. 5, pp. 453-455. , Harris, R. & Jenkinson, C. (2009). Quality of life in amyotrophic lateral sclerosis/motor neuron disease: a structured review.

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