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Download Basal Ganglia - A Medical Dictionary, Bibliography, and by Icon Health Publications PDF

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It is a 3-in-1 reference publication. It provides an entire scientific dictionary overlaying countless numbers of phrases and expressions with regards to basal ganglia. It additionally offers large lists of bibliographic citations. eventually, it offers details to clients on easy methods to replace their wisdom utilizing a variety of net assets. The publication is designed for physicians, clinical scholars getting ready for Board examinations, scientific researchers, and sufferers who are looking to get to grips with examine devoted to basal ganglia. in case your time is efficacious, this publication is for you. First, you won't waste time looking the net whereas lacking loads of correct details. moment, the booklet additionally saves you time indexing and defining entries. ultimately, you won't waste time and cash printing 1000s of websites.

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Additional info for Basal Ganglia - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References

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Professor; Neurology; Emory University 1784 North Decatur Road Atlanta, Ga 30322 Timing: Fiscal Year 2002; Project Start 01-JAN-1995; Project End 31-MAY-2004 Summary: (Verbatim from the applicant's abstract) Loss of striatal dopaminergic innervation in Parkinson's disease (PD) is associated with complex changes in the functional and neurochemical anatomy of the basal ganglia. Prominent among the neurotransmitters; altered in PD is the glutamatergic system. For example, the glutamatergic pathways from subthalamic nucleus to the internal segment of globus pallidus and the substantia nigra pars reticulata become overactive after nigrostriatal dopamine depletion.

This will be accomplished by completing the following specific aims: A) Determine the functional impact of METH-induced changes in NR2A subunit expression on NMDAR-mediated EPSCs in dorsolateral and ventromedial striatum. B) Examine the functional consequences of METH-induced changes in the monoamines and NR2A subunit expression on striatal LTP. The results of these studies will further elucidate postsynaptic changes associated with METH neurotoxicity, and will provide molecular insight into the behavioral and cognitive alterations which ensue a neurotoxic insult induced by METH.

During the award period, the applicant will develop expertise in the use of fMRI, cognitive and neuropharmacological techniques to study these disorders, and will continue to hone her clinical skills in the neuropsychological assessment of movement disorders. The applicant will apply these new techniques to investigate the role of dopamine in working memory. The specific aims of the proposed studies are to test the hypothesis that 1) PD affects prefrontal cortex involvement in working memory and 2) dopaminergic modulation of working memory primarily occurs due to changes in lateral prefrontal cortical activity.

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