By Juan Bilbao, Robert E. Schmidt
Peripheral nerve research is a not easy activity for pathologists, given the arrival of latest diagnoses and strategies of study and the influence of molecular genetics. This e-book provides an easy, logical strategy for developing a differential analysis in accordance with pathology and scientific presentation. It additionally presents suggestion at the number of ancillary molecular, immunohistochemical and genetic innovations to set up a definitive prognosis. transparent, authoritative counsel is accessible on prognosis of the whole diversity of neuropathies simply by a wealth of top of the range colour photomicrographs and electron micrographs. The pathologist will profit significantly from the id of a number of artifacts and general constructions sometimes encountered in nerve biopsies that must be distinct from particular pathologic adjustments. This undemanding, sensible textual content may be a useful relief achieve the main particular prognosis attainable.
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Additional info for Biopsy Diagnosis of Peripheral Neuropathy (2nd Edition)
Semin Neurol 18:7–18 Barohn RJ, Kissel JT, Warmolts JR et al (1989) Chronic inﬂammatory polyradiculoneuropathy. Clinical characteristics, course, and recommendations for diagnostic criteria. Arch Neurol 46:878–884 Bednarik J, Vlckova-Moravcova E, Bursova S et al (2009) Etiology of small-ﬁber neuropathy. J Peripher Nerv Syst 14:177–183 Behse F, Buchthal F, Carlsen F et al (1972) Hereditary neuropathy with liability to pressure palsies: electrophysiological and histopathological aspects. Brain 95:777–795 Bennett DLH, Groves M, Blake J et al (2008) The use of nerve and muscle biopsy in the diagnosis of vasculitis: a 5 year retrospective study.
In some laboratories, a 2 mm punch biopsy site for glabrous skin is chosen on the lateral aspect of the ﬁnger between the ﬁrst and second interphalangeal joint or on the tip of the third digit. Biopsy of glabrous skin is also useful to quantitatively evaluate axonal loss of myelinated nerve ﬁbers in patients with diabetic peripheral neuropathy (Peltier et al. 2013). Although neuropathic changes in hairy skin consist of axonal loss (Fig. 5a) and occasional axonal swellings, alterations in the distribution of myelinated axons in glabrous skin may differ from one dermal papilla to another (Fig.
J Neuropathol Exp Neurol 68:833–844 van Gameren II, Hazenberg BP, Bijzet J et al (2006) Diagnostic accuracy of subcutaneous abdominal fat tissue aspiration for detecting systemic amyloidosis and its utility in clinical practice. Arthritis Rheum 54:2015–2021 Vincent D, Dubas F, Haus JJ et al (1985) Microvasculites nerveuses et musculaires: 50 cas. Rev Neurol 141:440–446 Vital A, Beylot M, Vital C et al (1992) Morphological ﬁndings on peripheral nerve biopsies in 15 patients with human immunodeﬁciency virus infection.