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Extra resources for Breast cancer: new horizons in research and treatment
10 Halsted WS. John Hopkins Hosp Rep 1894-5; 4: 297-350. 11 Baum M. The history of breast cancer. ) Breast disease. Edinburgh: Churchill Livingston, 1986: 95-105. 12 Brinkley D, Haybittle JL The curability of breast cancer. Lancet ^73;2: 95-8. 13 Bloom HJG, Richardson WW, Harries EJ. Natural history of 27 Fisher B, Fisher ER, Redmond C. Ten-year results from the National Surgical Adjuvant Breast and Bowel Project (NSABP) clinical trial evaluating the use of L-phenylalanine mustard (i-PAM) in the management of primary breast cancer.
Annu Rev Cell Biol 1990; 6: 597-641. 71 Roberts AB, Anzano MA, Wakefield LM, Roche NS, Stern DF, Sporn MB. Type b-transforming growth factor: a bifunctional regulator of cellular growth. Proc Natl Acad SciUSA 1985; 82:119-23. 72 Tucker RF, Shipley GD, Moses HL, Holley RW. Growth inhibitor from BSC-1 cells is closely related to the platelet type transforming growth factor. Science 1984; 226: 705-7. 73 Arteaga CL, Tandon AK, Von Hoff DD, Osborne CK. Transforming growth factor (3: potential autocrine growth inhibitor of oestrogen receptor negative human breast cancer cells.
It remains unresolved whether altered levels of these growth factors are directly implicated in processes of carcinogenesis. However, the pharmacological manipulation of growth factors is a realistic strategy for both treatment of established tumours and prevention of malignancy. 87 Derangements of mesenchymal-epithelial interactions based on aberrant stromal phenotypes could be expoited clinically if the latter permitted induction of inhibitory paracrine growth factors such as TGFb, or suppression of positive ones.