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By H.-J. Senn, U. Kapp

This quantity comprises the most complaints of the fourth foreign convention on "Cancer Prevention 2006," which used to be held in the course of February 16–18, 2006, in St. Gallen, Switzerland. Written by way of foreign specialists within the box, the e-book includes a entire replace at the newest advancements within the upsurging fields of molecular biology and melanoma genetics and their interactions with scientific epidemiology and melanoma prevention at quite a few levels.

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Extra resources for Cancer Prevention

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A case–control analysis by histologic type. Am J Epidemiol 138:281–293 Risch A, Wikman H, Thiel S, Schmezer P, Edler L, Drings P, Dienemann H, Kayser K, Schulz V, Spiegelhalder B, Bartsch H (2001) Glutathione-S-transferase M1, M3, T1 and P1 polymorphisms and susceptibility to non-small-cell lung cancer subtypes and hamartomas. Pharmacogenetics 11:757–764 Rosell R, Taron M, Ariza A, Barnadas A, Mate JL, Reguart N, Margel M, Felip E, Mendez P, Garcia-Campelo R (2004) Molecular predictors of response to chemotherapy in lung cancer.

Constitutive mRNA expression profiles were analyzed for predicting acute clinical radiosensitivity (Hümmerich et al. 2006). Cluster analysis identified 19 differentially expressed genes. Many of these genes are involved in DNA double-strand break repair. Expression levels of these genes differed up to sevenfold from the mean of all patients, whereas expression levels of housekeeping genes varied only up to twofold. High expression of the identified genes was associated with a lack of clinical radiation sensitivity.

Nature 429:464–468 Fijneman RJA (2005) Genetic predisposition to sporadic cancer: how to handle major effects of minor genes? Cellular Oncology 27:281–292 Fischer JR, Lahm H (2004) Validation of molecular and immunological factors with predictive importance in lung cancer. Lung Cancer 45:S5151–S1617 Gautschi O, Hugli B, Ziegler A, Bigosch C, Bowers NL, Daniel Ratschiller D, Jermann M, Stahel RA, Heighway J, Betticher DC (2006) Cyclin Dl (CCND1) A870G gene polymorphism modulates smokinginduced lung cancer risk and response to platinumbased chemotherapy in non-small cell lung cancer (NSCLC) patients.

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