By J. T. Grayston, S.-P. Wang (auth.), Luigi Allegra, Francesco Blasi (eds.)
Chlamydia pneumoniae is now famous as an incredible human pathogen. Chlamydia pneumoniae is excited about 5%-15% of neighborhood obtained pneumonias, and up to date facts point out its relevance in critical pneumonia and as a respiration pathogen in immunocompromised matters. A causal position for Chlamydia pneumoniae within the initiation, exacerbations and merchandising of bronchial asthma has been steered. nearly five% of persistent bronchitis exacerbations were attributed to Chlamydia pneumoniae infections, and protracted an infection might facilitate entry of alternative pathogens to the reduce breathing tract. one other box of power nice social effect is the prospective involvement of Chlamydia pneumoniae within the pathogenesis of atherosclerosis and similar cardiovascular illnesses. This booklet provides the present cutting-edge wisdom on Chlamydia pneumoniae an infection and highlights destiny strains of research.
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Additional info for Chlamydia pneumoniae: The Lung and the Heart
For primary infection, the CF test has a sensitivity of 60%. In re-infection, LPS antibodies are rarely detectable, giving CF tests a sensitivity of only approximately 10% [20-23]. Whole Inclusion Fluorescence Antibody detection kits are available in which the source of antigen is cells infected with a lymphogranuloma strain (LGV) of C. trachomatis, fIxed on a glass slide. The sensitivity and specifIcity of these kits for the serodiagnosis of C. pneumoniae infection has not been widely evaluated.
Pneumoniae infection, for defining the epidemiology of disease and for research into the pathogenesis of chlamydial infections [1, 2]. These laboratory methods include culture, antigen detection, serology and the polymerase chain reaction (PCR). Early seroepidemiological studies were based on the micro-immunofluorescence (MIF) assay, originally developed for C. trachomatis. As the conditions for culture of C. pneumoniae become optimised, antigenic and genetic differences of strains from around the world were documented.
Messmer TO, Skelton SK, Moroney JF, Daugharty H, Fields B (1997) Application of a multiplex PCR to psittacosis outbreaks. J Clin MicrobioI35:2043-2046 Chlamydia pneumoniae Infections: Applications of Laboratory Methods 41 20. Grayston JT, Campbell LA, Kuo C-C et al (1989) A new respiratory tract pathogen: Chlamydia pneumoniae strain TWAR. J Infect Dis 161:618-625 21. Grayston JT, Aldous MB, Easton A, Wang S-P et al (1993) Evidence that Chlamydia pneumoniae causes pneumoniae and bronchitis. J Infect Dis 163:1231-1235 22.