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Download Design of the National Children's Study : a workshop summary by Kirkendall, Nancy J. PDF

By Kirkendall, Nancy J.

"The kid's well-being Act mandated the nationwide kid's research (NCS) in 2000 with one in all its reasons being to authorize the nationwide Institute of kid future health and Human improvement (NICHD) to check the environmental impacts (including actual, chemical, organic, and psychosocial) on kid's overall healthiness and improvement. The NCS examines all points of our environment together with air, water, vitamin, noise, family  Read more...

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Every additional birth to a first-time pregnant mother drawn from the pre­ natal providers would reduce the number of sibling births that could be enrolled in the study by between 4 and 10 children. Garfinkel concluded that his analysis identifies the key scientific questions underlying the choice between the size of the prenatal and birth cohorts: How important are early prenatal data? How important are preconception data? Is the fundamental biology of harm different for environmental exposures for first and subsequent births?

Prenatal information on first births is important; if the study resulted in no prenatal data on pregnancies to women delivering for the first time, important scientific questions would remain unanswered. Garfinkel referred to the previous panelists (see Chapter 2), who stated they are not aware of evidence that the biology of exposures differs by first and subsequent births. Bracken replied that the biology of exposures is only half of the question: The question remains how these exposures interact with a developing fetus and said many examples may indicate that the developing first-pregnancy fetus is not identical to subsequent developing fetuses.

The Birth Cohort consists of births collected from a sample of hospitals and birthing centers and a subsample of women giving birth at those ­selected centers. This is tentatively planned to be about 45,000 participants of the overall sample. A 2-year initial recruitment period is proposed. Within the current proposal, for each selected geographic PSU, a list of all hospitals and birthing centers will be prepared as a sampling frame for the birth cohort. Based on data from 2006, roughly 98 percent of all births in the United States take place at hospitals or birthing centers.

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